Toxicity studies of metabolites of some fungal isolates in albino mice.
نویسندگان
چکیده
Crude metabolites of 21 of 60 fungal cultures isolated from some of the common cereals collected from different parts of India were found to be toxic. Of these toxin-producing fungi, 79% caused hepatic pathology of varying severity in mice. Serum glutamate pyruvate transaminase values and blood urea nitrogen were found to be high in such experimental animals.
منابع مشابه
Histopathology of Mycotoxicosis produced in Swiss albino mice by metabolites of some fungal isolates.
Of 199 fungal cultures isolated from some of the common cereals collected from different parts of Uttar Pradesh and Madhya Pradesh, 70 produced toxic metabolites. Of the 70 fungi isolated, 59 produced toxins which caused visible lesions in livers, kidneys, and spleens but did not cause mortality. Toxicity, graded in terms of the mortality rate and the extent of lesions in livers, kidneys, and s...
متن کاملAttenuation of N-nitrosodimethylamine induced hepatotoxicity by Operculina turpethum in Swiss Albino mice
Objective(s): To appraise the antihepatotoxic efficacy of ethanolic extract of Operculum turpethum root on the liver of Swiss albino mice. Materials and Methods: Hepatic fibrosis was induced in adult male albino mice through intraperitoneal administrations of N-nitrosodimethylamine (NDMA) at the concentration of 10 mg/kg body weight. The liver toxicity and therapeutic effect of the ...
متن کاملAn investigation on some toxic effects of pyriproxyfen in adult male mice
Objective(s): Pyriproxyfen as an insect growth regulator is widely used globally for pest management. There are reports on adverse effects of insecticides such as organ toxicity, endocrine disruptions, and teratogenicity in animals and humans. We aimed to investigate reproductive toxicity of pyriproxyfen in adult male mice.Materials and Methods:</stro...
متن کاملP-155: Studies of Cytotoxic Effects ofCdSe Quantum Dots on Fetal Development Testis and Epididymis in Albino Mice
Background: Quantum dots (QDs) are among the most promising items in the nanomedicine toolbox. These nanocrystal fluorophores have several potential medical applications including nanodiagnostics, imaging, targeted drug delivery, Nevertheless, in vivo cytotoxicity of these nanoparticles has not been highly considered. For this reason, the cytotoxic effects of CdSe QDs on testis and epididymis e...
متن کاملHistological and Biochemical Changes in the Liver of Albino Mice on Exposure to Insecticide, Carbosulfan
Carbosulfan (2,3-dihydro-2,2dimethyl-7-benzofuronyl [(dibutyl amino) thio] methyl] a carbamate insecticide and acaricide was administered orally at an effective dose of 48 mg/kg/day to albino mice for 5, 10, 20 and 30 days .Control mice received similar quantities of olive oil. Daily body weights were recorded and mice were sacrificed after 24 hours after the terminal exposure. The histologic e...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Applied and environmental microbiology
دوره 46 6 شماره
صفحات -
تاریخ انتشار 1983